Uncover overrepresented cancer hallmarks

Step #1 - enter gene list Look up gene names Load sample genes

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Step #2 - select gene set

Integrated cancer hallmark gene set (n=6763) Core cancer hallmark gene set (n=1574) Molecular Signatures Database Gene Set (MSigDB)

Human Mouse

Enrichment plot Enrichment with distribution plot

Step #3 - submit

What are the Hallmarks of Cancer?

The "Hallmarks of Cancer" concept provides a framework for understanding fundamental organizing principles common to various cancers. Understanding hallmarks can benefit cancer prevention, diagnosis, and treatment development by summarizing functional and metabolic commonalities underlying malignant transformation and progression.

What can CancerHallmarks do?

We established a consensus list of cancer hallmark genes by merging 6,763 genes from available mapping resources. CancerHallmarks.com enhances the utility of the hallmark concept as an effective organizational tool by funneling genes to biological functions.

Please kindly cite our paper to support further development: Menyhart O, Kothalawala WJ, Gyorffy B: A gene set enrichment analysis for the cancer hallmarks, Journal of Pharmaceutical Analysis, 2024, https://doi.org/10.1016/j.jpha.2024.101065

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